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Excess B12 from oral supplements is poorly absorbed at high doses (the body absorbs roughly 1 to 2% of a 1,000 mcg oral dose) and the remainder is excreted in urine

The whole process really breaks down into two parts: first, figuring out how much solvent to add to get the concentration you want, and second, calculating how much of that solution to draw for a specific dose

The slow titration (125 mcg weeks 1-4, then 250 mcg weeks 5-8) mimics FDA-approved protocols that emphasize gradual increases for tolerability

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Phase II detoxification is the process by which the glutathione glutathione binds to xenobiotics (toxins, drugs, pollutants) via the enzyme glutathione-S-transferase (GST)