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10.1080/10245332.2018.1456023 52 SharabiA.CohenE.SulkesJ.GartyM
Anti-aging applications Peptides for anti-aging span multiple categories: Epitalon targets telomerase and cellular aging mechanisms
It helps balance NO levels to protect the endothelial lining of blood vessels, ensuring they remain flexible and resilient rather than inflamed
Reported applications include NNMT enzyme inhibition assays measuring 1-methylnicotinamide formation or S-adenosylhomocysteine release, intracellular target-engagement assays in differentiated 3T3-L1 adipocytes where 5-Amino-1MQ reduced intracellular 1-methylnicotinamide with an EC near 2.3 M (Neelakantan et al., Biochem Pharmacol, 2018), membrane permeability and Caco-2 transport characterisation, methyltransferase selectivity panels covering COMT, DNMT1 and PRMT3, and rodent studies of NNMT inhibition in adipose tissue and liver following the antisense knockdown work of Kraus and colleagues (Nature, 2014)
This ensures safe and effective treatment for a wide range of patients
