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This inflammatory synovial fibroblast phenotype exacerbates cartilage degeneration, via the induction of matrix metalloproteases (MMPs) and aggrecanases (ADAMTS4/5), and sensitises the growth and activity of joint nociceptors [92,93,94]
Outside that window, the brand states replacements generally can't be approved - though they note occasional exceptions for situations like hospitalization
doi: 10.3389/fmicb.2016.02173 61 WHO (2022)
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