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For patients already on venlafaxine at doses 150 mg/day (where NET inhibition becomes clinically relevant), adding an uncharacterized vasopressive modulator creates a monitoring burden that cannot be managed without serial blood pressure measurement

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The pattern in patient reviews: those reporting substantial weight loss (10+ pounds in 4 weeks) invariably mention concurrent dietary changes, increased exercise, or use of other medications (metformin, GLP-1 agonists)

Experimental application must remain within controlled, in vitro environments

Animal studies show significant acceleration in wound healing