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All of these medications have FDA-boxed warnings

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[25] The magnitude and direction of phase shifts induced by exogenous melatonin depend on several factors, including the dose, timing of administration relative to the individuals endogenous circadian phase, and the patients sensitivity to melatonin

This pattern aligns with findings from CANVAS [42], CREDENCE [60], and DAPA-CKD [58], in which greater absolute eGFR preservation was noted in participants with higher baseline albuminuria

Suing thousands of small entities is prohibitively expensive and yields low damages per case