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GHK-Cu is stable at physiological pH (6.57.5) but dissociates below pH 4 or above pH 9, releasing free copper, which can be pro-oxidant if unbound
The framework prioritised semaglutide and tirzepatide as first-line treatments, based on evidence of 15% weight loss and benefits in complications such as cardiovascular disease and sleep apnoea
Planning for this rebound, maintaining dietary structure, exercise habits, and potentially transitioning to alternative interventions, is essential for anyone discontinuing cagrilintide
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