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The major inner mitochondrial membrane (IMM) localized transporter responsible for mitochondrial uptake of calcium is the MCU (mitochondrial calcium uniporter)

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This takes over an eminent function in the monitoring of cellular processes such as gene expression levels, DNAprotein interactions, differentiation at cellular level, embryogenesis, aside from genomic imprinting (Reference Stotz13,Reference Das, Parbin and Pradhan14)