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[2]Chen, M

Eliason MJ, Leachman SA, Feng BJ, Schwartz ME, Hansen CD

The mean change in quality of life, as determined by Kansas City Cardiomyopathy Questionnaire (KCCQ) clinical summary scores, was 13.7 points for the semaglutide group and 6.4 points for the placebo group

As a selective melanocortin 1 receptor (MC1R) agonist, afamelanotide is applied in experimental settings to probe the cAMP-mediated melanogenesis cascade the intracellular signaling pathway through which MC1R governs pigmentation biology in melanocyte cell models

Without that clinical context, its easy for associations to be made that arent necessarily causal