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Together, these findings identify the IFN-I- Chac2-GSH pathway as a key driver of systemic immune remodeling in periodontitis

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Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice