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The most common side effects are gastrointestinal in nature and typically diminish over time as the body adjusts to the medication

& Hammond, C

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After 72 weeks: Participants taking 5 mg of tirzepatide lost 15% of their starting body weight on average Those taking 10 mg lost an average of 19.5% Those taking the highest dose, 15 mg, lost an average of 20.9% Another phase 3 clinical trial studied the efficacy of once-daily orforglipron in people with obesity and found that it resulted in significant weight loss compared to placebo

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