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Depression: A meta-analysis of 5 RCTs (n=574) found that NAC significantly improved depressive symptoms, particularly in individuals with high baseline symptom severity (Fernandes et al., J Clin Psychiatry, 2016) [73]
It correlates with increased insulin resistance over time
PMID: 28698222
While limited formal research exists on combination protocols, clinical experience and mechanistic understanding provide guidance on potentially synergistic approaches
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