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You must meet all of these criteria: Sleep Apnea Coverage Requirements (All Must Be Met) You must be 18 or older BMI of 30 or higher Sleep study results showing moderate-to-severe sleep apnea (your sleep study score, called AHI or similar, must be greater than 15 events per hour) Sleep apnea symptoms excessive daytime sleepiness, loud snoring, choking/gasping during sleep, or trouble staying asleep Tried to lose weight before (at least one documented attempt) CPAP machine requirement you must have either: Tried CPAP (used 4+ hours/night, 70%+ of nights) but still have symptoms, OR Can't use CPAP for medical reasons No diabetes your A1C (blood sugar test) must be 6.5% or lower Sleep specialist involvement must be prescribed by or in consultation with a sleep specialist Received counseling on sleep position and avoiding alcohol/sedatives before bed No planned surgeries for sleep apnea or weight loss Must be obstructive sleep apnea only not central or mixed types To keep coverage: After 12 months, you'll need to show at least 10% weight loss and improved sleep study scores to continue on Zepbound

The dietary flavone luteolin epigenetically activates the Nrf2 pathway and blocks cell transformation in human colorectal cancer HCT116 cells

There has also been impact on decreasing the chance of developing or recurrent cardiovascular disease such as heart attacks or stroke.

GLP-1 RA is an abbreviation that stands for glucagon-like peptide-1 receptor agonist

doi: 10.1159/000180515 79 DaveyRAFindlayDM