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Matrix Metalloproteinases Inhibitors MMPs are key drivers of BBB disruption through proteolytic cleavage of basement membrane and TJ proteins, including ZO-1, claudin-5, and occludin, thereby serving as critical mediators of CNS

Quick refresher on free radicals: these can be caused by environmental factors such as pollution, UV radiation, and cigarette smoke, as well as internal factors such as inflammation and metabolism

[5] Neuromodulator [edit] GSSG, along with glutathione and S -nitrosoglutathione (GSNO), have been found to bind to the glutamate recognition site of the NMDA and AMPA receptors (via their -glutamyl moieties), and may be endogenous neuromodulators

Current insights into the risks of using melatonin as a treatment for sleep disorders in older adults

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