retatrutide glp-1 gip glucagon receptor agonist (Eli Lilly's triple GLP-1/GIP/Glucagon agonist) just delivered the most impressive obesity + osteoarthritis data we've ever seen in the phase 3 TRIUMPH-4 trial: TrimRX | GLP-1 vs GIP:

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Standard semaglutide titration: Weeks 1-4: 0.25 mg weekly Weeks 5-8: 0.5 mg weekly Weeks 9-12: 1.0 mg weekly Week 13+: 1.7 mg or 2.4 mg weekly (target dose) Hashimoto's-adjusted approach: Weeks 1-6: 0.25 mg weekly (extended to allow thyroid monitoring at week 6) Weeks 7-12: 0.5 mg weekly (TSH check before increasing) Weeks 13-16: 1.0 mg weekly Week 17+: Assess whether higher doses are needed The extended timeline allows for thyroid function checks at each step, ensuring levothyroxine doses are adjusted proactively rather than reactively

300K+ members served Wide, affordable medication toolkit semaglutide Ozempic $1100/mo semaglutide Wegovy from $650/mo+ tirzepatide Zepbound from $650/mo+ tirzepatide Mounjaro ~$1100/mo liraglutide Saxenda Pricing varies liraglutide Victoza Pricing varies Found is not affiliated or endorsed by Novo Nordisk A/S., the owner of the registered trademarks Wegovy, Ozempic, Saxenda, Rybelsus, and Victoza, nor is it affiliated or ensorsed by Eli Lilly & Co., the owner of the registered trademarks Trulicity, Zepbound, and Mounjaro

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