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Steve Kates, a longtime pharmaceutical executive and expert in peptide design and manufacturing, said one of the chief concerns with some of these peptides is that they have not undergone rigorous, long-term testing typically consistent with FDA-approved medications

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The difference between the groups increased when evaluated at d 56 (28 d following last dose) at which point the mean improvement in the ARA 290 had increased to 4.2, and the placebo group diminished to 0.74 points