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Nausea, constipation, and mild headache are typical early side effects, usually resolving within 23 weeks

However, some endocrinologists consider metformin when patients demonstrate concurrent insulin resistance or prediabetes alongside their thyroid condition

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High-sensitivity C-reactive protein (hs-CRP) , an acute-phase reactant produced by the liver in response to inflammatory cytokines, serves as a widely used marker of systemic inflammation and cardiovascular risk

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