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Siponimod (BAF312) activates Nrf2 while hampering NFB in human astrocytes, and protects from astrocyte-induced neurodegeneration
Each has its own dosing plan tailored to specific needs
12 Combinatorial approaches involving DDR inhibitors, epigenetic modulators, metabolic disruptors and immunotherapeutics hold promise for overcoming resistance and achieving durable clinical responses across malignancies
Expert Opinion on Biological Therapy (2012) 11
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