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When LPS enters the bloodstream, it strongly activates the immune system, leading to the massive release of pro-inflammatory cytokines and the generation of large amounts of ROS, ultimately resulting in hepatocyte death and acute liver injury (Zhang G
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Both crystallography studies and structural models suggest that IgG binds to FcRn in an upside-down orientation, such that the Fab arms face down towards the membrane in which FcRn is embedded [34, 61]
Yu Y, et al
Reproductive biology and endocrinology : RB&E
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