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After adjusting for age group, gender, BMI, Smoking cessation aid use, and duration of GLP-1 use, higher BMI was associated with greater odds of reduced smoking behavior compared with no change (adjusted odds ratio [aOR] 1.13 per kg/m 2 , 95% CI 1.061.21

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The safety, tolerability, and pharmacokinetics of PF-06882961 were evaluated in a first-in-human, Phase 1, randomized, double-blind, placebo-controlled, single ascending dose study in healthy adult participants