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Preclinical studies have demonstrated that NCoR1 depletion, followed by treatment with rapamycin, anti-mycin-A, or metformin restored TFEB activity and LC3 levels, leading to improved clearance of M.tb [28]
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Since then, several more GLP-1 agonists have been approved by the FDA
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Finally, delineating tissue-preferential effects is essential to determine whether improvements in IR arise primarily from reduced hepatic lipid content or also involve amelioration of pancreatic steatosis and skeletal muscle lipid metabolism
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