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Size and zeta potential measurements were conducted on a Malvern Zetasizer (Nano ZS, UK)

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The comparator consisted of patients who had never used a GLP-1 receptor agonist-SGLT-2 inhibitor combination up until the time of the interval and had received a prescription for the background drug at that 30 day interval

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Single receptor agonists, liraglutide and semaglutide, were not shown to measurably cross the BBB, implying that these GLP-1 receptor agonists may influence brain function indirectly and act at brain regions outside the BBB [21]