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Discontinuation due to side effects ran at 7% in Phase 2 data, which is lower than Semaglutides 11% discontinuation rate despite Semaglutide having a higher reported nausea incidence at 44%

Furthermore, a therapy with dipyridamole, which is now recognized as a potent antioxidant, can prevent the development of early atherosclerotic intimal lesions (which are composed of proliferating smooth muscle cells surrounded by large amounts of collagen, elastic fibers, and glycosaminoglycans) that are observed in hyperhomocyst(e)inemic baboons (Harker et al, 1976)

however, in such cases, a prooxidant effect cannot be excluded