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Interestingly, constipation was more prevalent in the dulaglutide group (29.4%) compared with the semaglutide group (10.9%), and nausea was slightly more common with semaglutide
[1] The effects on the CYP3A4 in the liver could, in principle, cause interactions with non-CYP3A4-mediated effects
p = 0.18), suggesting no significant difference in efficacy between Semaglutide and Liraglutide (Figure 8)
The Journal of physiology, 589(Pt 4), 963973
Untreated Controls Preclinical injury models % reduction in healing time Tendon Transection (Rat Achilles model)50% Skin Wound Closure (Alkali burn model)45% Muscle Crush Injury (Rat quadriceps)40% Safety Data Safety Profile from Research What preclinical and early clinical studies report Preclinical Safety Summary LD50Not achieved Acute toxicityNone observed Chronic toxicityNone in 6-month studies Organ toxicityNone detected Human IV pilot (n=2)No adverse effects Cardiac/hepatic/renalNo effects detected Regulatory & Risk Considerations FDA statusUnapproved drug WADA statusBanned since 2022 (S0) Human trialsPhase 1 only Long-term effectsUnknown in humans Pro-angiogenic riskTheoretical unstudied Australia/NZPrescription only No lethal dose was reached in preclinical toxicology studies
