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There are a few reasons for this: More complex manufacturing process The acetylation step requires specialized equipment and quality control
The label indicates it is not being sold as an approved human medicine
As an example, in the DURATION-8 study, while combination therapy produced greater HbA1c and body weight reductions, the effect was less than additive compared to the sum of individual drug effects, most likely because the efficacy of glucose-lowering therapies can depend on baseline glycaemic control [24]
those switched to placebo regained about 14% over the next year. Weight loss slows toward a plateau on a held dose rather than continuing indefinitely
J Nephrol
