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That opportunity is now supported by manufacturing commitments, including Novo Nordisk's March 2026 announcement of a EUR 432 million expansion in Athlone, Ireland, to increase capacity for oral GLP-1 therapies, alongside Eli Lilly's November 2025 plan to build a USD 3 billion manufacturing facility in Katwijk, the Netherlands, aimed at oral medicines including the GLP-1 receptor agonist orforglipron
The promising results from the Phase III SOUL trial, which demonstrated a 14% reduction in MACE occurrence with Rybelsus, have further validated its role in cardiovascular disease prevention
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Traditional swallowed forms have limited effectiveness due to digestive breakdown, but sublingual troches and liposomal formulations improve absorption significantly
HbA1c, which reflects average blood sugar over 2-3 months, dropped by up to 2.5 percentage points
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