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Immunofluorescence analysis of PC-12 cells using Glutathione Synthetase Rabbit pAb at dilution of 1:100
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To demonstrate the advantages of bivalent target binding through the full IgG format for enhancing avidity and selectivity, compared to most clinically approved bispecific T cell engagers that rely on monovalent binding, we introduced mutations (H91A and Y92A) in the complementarity-determining regions of Her2 to generate Her2 variants with reduced target binding affinity
Within experimental models, it is commonly investigated for its interaction with NNMT-associated pathways and molecular signalling mechanisms