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Investigators administered BPC-157 by three routes intraperitoneal injection, oral administration in drinking water, and topical application as a thin cream layer with assessment over a 90-day post-injury period

However, achieving efficient oral peptide delivery remains challenging as peptides are rapidly degraded by gastrointestinal enzymes, their hydrophilic nature limits transcellular permeation, and their relatively large molecular size restricts paracellular transport

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Harazin A, Bocsik A, Barna L, Kincses A, Vradi J, Fenyvesi F, et al