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A companion mechanistic paper, Chang et al., Molecules 2014, found that the peptide up-regulated growth-hormone-receptor expression in tendon fibroblasts at both mRNA and protein levels, potentially sensitising these cells to growth hormone during repair
The peptide stimulates production of VEGF (vascular endothelial growth factor) and HGF (hepatocyte growth factor), both critical for building new capillary networks
How It Develops Most intolerance begins early in treatment
Neuropharmacology 155, 5464
Biological analyses were performed on stool samples (16S rRNA sequencing) and blood serum (ELISA for oxytocin, inflammatory and neuroinjury markers), while behavioral outcomes were assessed using SRS, ABC and CGI
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