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The anabolic:androgenic ratio remains an important pharmacological benchmark, but clinical outcomes vary based on receptor interactions, metabolism, and dosing protocol. Kicman, British Journal of Pharmacology Other Factors That Define Potency Receptor binding affinity : How strongly a steroid binds to androgen receptors Results per milligram : How much strength gain is produced per dose Muscle retention : Especially during cutting cycles or calorie deficits Some steroidslike Trenbolonehave an exceptionally high receptor binding affinity, making them ultra-potent in small doses but also more side effect-prone