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Certain Bulk Drug Substances for Use in Compounding That May Present Significant Safety Risks

a recent safety analysis found no anaphylaxis in hundreds of patients receiving high-dose IV thiamine, suggesting the risk is very low in practice

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This effect is believed to be on-target, as liver-specific FDFT1 knockout mice exhibited a similar increase in liver enzymes and a build-up of isoprenoid precursors 26

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