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In addition to these canonical reactions, both enzymes have been proposed to produce H 2 S by utilizing alternative substrates, namely, a combination of cystine and homocysteine for CBS and either cysteine or homocysteine for CSE (Sbodio et al., 2019)

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Findings from TCGA and other studies have revealed that around 40% of HNSCC harbour genomic alterations in cell death pathways [13, 14]

These approaches aim to alter gene expression in follicle cells to permanently overcome the signaling defects that cause hair loss