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In addition, we proposed a pharmacological treatment algorithm for healthcare professionals, which could provide guidance in working toward an individualized pharmacological management of patients with IBS-D
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DSIP appears to interact with NMDA receptors, components of the MAPK signaling cascade, and glucocorticoid pathways
In addition, small molecule inhibitors including SLC7A11 inhibitor HG106 and GCLC inhibitor buthionine sulfoximine (BSO) were introduced to investigate their effects on ROS, GSH levels and cellular viability in VRK2-KO and VRK2-KD cells, and the results were consistent with the above knockdown experiment (Fig
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