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David Joffe, BSPharm, CDE Tina Burge, PharmD Candidate Florida A&M University Kiet Ngo, Pharm D Candidate Mercer University Abnormalities in incretin hormones such as the glucagon-like peptide-1 (GLP-1) contribute to the development of hyperglycemia

Tirzepatide is a novel glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for two distinct indications: type 2 diabetes mellitus (marketed as Mounjaro) and chronic weight management (marketed as Zepbound)

Patients should be educated to report symptoms of thyroid dysfunction, including palpitations, tremor, heat intolerance, anxiety (suggesting hyperthyroidism), or fatigue, cold intolerance, and weight gain (suggesting hypothyroidism)

Oral semaglutide requires higher doses to achieve similar effects because the digestive system breaks down much of the peptide before absorption

DOI.org (Crossref) , PLoS ONE , vol