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29:45 - The Four Finalists (and Why Three Failed) The first candidate was a potato extract that was quite active, but it turned out to be contaminated with toxic glycoalkaloids (alpha-solanine and alpha-chaconine) the compounds that make green potatoes poisonous
Approval is generally six to twelve months after submission, assuming no issues
The most commonly reported side effects in Phase 2 trials were gastrointestinal, including nausea, vomiting, diarrhoea, and constipation, which were generally mild to moderate and tended to improve over time
These effects include reduced inflammation [9, 10], improved mitochondrial biogenesis and function [11, 12], preservation of the blood-retinal barrier [13, 14], and increased retinal vascularization [15]
As an example, one case study involving someone with a history of alcoholic pancreatitis tied an acute pancreatitis episode to starting semaglutide three months before
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