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427,428,429 The compound NLY01 is particularly effective at attenuating the activity of proinflammatory microglia and preventing the transformation of astrocytes to a reactive phenotype

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Symptoms of elevated blood glucose include increased thirst, frequent urination, fatigue, and blurred vision

PKA inactivates K + channels [ATP-sensitive K + (K ATP ) channels and voltage-gated K + (K v ) channels], leading to depolarization, Ca 2+ influx, and ultimately insulin release (39)

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