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PubMed PMID: 24480491

Large, high-fat meals are the most common trigger for post-injection nausea because semaglutide slows gastric emptying, and a heavy meal sitting in a slow-moving stomach is a recipe for discomfort

It resists dramatic changes in hormone levels from dietary inputs, which is actually a protective feature, not a limitation to overcome

That still supports once-weekly dosing, and it also means the medication does not disappear immediately if you miss a dose or stop treatment

Step 3: Perform the visual inspection After the medication has cooled in the refrigerator for 30-60 minutes, remove it and perform the visual inspection described above