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Notably, the full spectrum of clinical features associated with B12 deficiency is much broader, is nonspecific, and may occur as a consequence of other diseases

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This not only protects the cardiovascular system from oxidative damage and clotting risks but also shields the brain from homocysteine-induced neurotoxicity

Combined with DSIPs U-shaped dose-response curve, this creates serious uncertainty

[20] Pernicious anemia [edit] Pernicious anemia is a disease caused by an autoimmune response that produces antibodies that attack the parietal cells in the stomach lining, preventing them from creating intrinsic factor needed for the absorption of vitamin B 12