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It is typically not recommended for patients with hepatic or renal impairment, uncontrolled hypertension, history of pancreatitis, or medullary thyroid cancer risk
The Core Difference: Two Receptors vs Three Tirzepatide activates: GLP-1 receptor (appetite suppression, glucose control) GIP receptor (synergistic metabolic effects) Retatrutide activates: GLP-1 receptor GIP receptor Glucagon receptor (thermogenesis, direct fat oxidation) That third receptor is the key difference
doi:10.1016/S0140-6736(11)60205-5
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