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however, other recent work has indirectly suggested an unfavourable association between L-C and cardiovascular risk factors [22, 23]
Acknowledgements This work has been supported by National Natural Science Foundation of China grants (W2412122, 82470195, 82200208), Natural Science Foundation of Tianjin grants (24JCYBJC00780, 24ZXZSSS00050), State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine grants (QZ 23-6, 23-4), Jin Men Medical Talents of Tianjin (TJSJMYXYC-D2-039), Clinical Oncology Research Fund of CSCO grant (Y-2024AZ(BTK)MS-0040) and Tianjin Key Medical Discipline (Specialty) Construction Project grant (TJYXZDXK-009A)
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Thus, both enzymes also contribute to the signal transduction processes that lead to specific gene expression by regulating the mitochondrial and cytosolic concentration of the diffusible signaling molecule H 2 O 2 (del Ro et al., 1996)
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