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Methionine loading (sustained intake above 34g/day from all sources, including dietary protein) can elevate homocysteine to levels associated with increased cardiovascular risk

Hazen explains that it all goes back to the Great Depression, when food shortages led people to experience health issues related to nutritional deficiencies including pellagra, aka niacin deficiency

doi: 10.1148/radiol.14141079 49 BuchwaldDCheneyPRPetersonDLHenryBWormsleySBGeigerAet al

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That is among the highest averages ever reported for a weight-loss medication, which is why retatrutide is considered such a promising step forward