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GLP-1R-LepR co-expressing neurons, localized primarily in the DMH in rodent and non-human primate models, mediate the suppression of food intake by liraglutide [74-76]
A 0.5mg dose requires 30 units instead of 20
And at higher doses , the math scales linearly
Key Innovation: The addition of a C18 fatty diacid side chain extends its half-life to approximately 7 days, enabling once-weekly dosing similar to modern GLP-1 receptor agonists
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