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The review identified 13 eligible trials and noted that 200 to 450 milligrams per day appears to be a safe and potentially effective range for supporting healthy sleep in adults

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Pulsatile GH release from CJC-1295 preserves hypothalamic-pituitary negative feedback, reducing (though not eliminating) the risk of supraphysiologic GH spikes that can occur with direct GH administration 2

Dosage, method of administration, and the persons existing health condition are determining factors in terms of safety