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47 Taken together, these data suggest the reduced GSH/GSSG antioxidant capacity is insufficient to counter excessive OH production, and that unopposed OH can reach the nucleus to create the oxidative DNA adduct, 8-oxo-dG

Among the main findings of the research, we highlight that the supplements of greatest clinical relevance in the treatment of PCOS are characterized by being aimed at the progressive improvement of the most frequent clinical manifestations in patients, thus encompassing four important parameters to achieve an efficient result: glycemic control, dyslipidemia control, reduction of oxidative stress, and hormonal control (Figure 1)

Antioxidant and redox-protective strategies may therefore preserve both cellular structures and the cofactors required for bioenergetic recovery

It is the body's primary intracellular antioxidant, operating in both the cytosol and mitochondria, and is directly responsible for regenerating Vitamin C, Vitamin E, and alpha lipoic acid

Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al