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Early clinical trial data, most notably from the Phase 2 trial published in the New England Journal of Medicine (Jastreboff et al., 2023), demonstrated that retatrutide produced substantial reductions in body weight up to approximately 24% over 48 weeks at the highest doses studied

Moreover, Ozempic is designed to target specific receptors involved in blood sugar regulation and appetite control, not the reproductive hormones responsible for menstruation

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