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10.1111/ejn.14720 210
Everything else is shared, a 23-membered macrocycle closed by a lactam bridge between the aspartate side-chain carboxyl at position 5 and the lysine side-chain amine at position 10, norleucine at position 4 in place of the oxidation-prone methionine of the native hormone, and D-phenylalanine at position 7 inside the conserved His-Phe-Arg-Trp message core
These results approach the efficacy of Roux-en-Y gastric bypass surgery, which typically produces 25-30% weight loss at one year
It also depends on how well the body absorbs it
To confirm that LaccID labeling depends on O 2 , we depleted O 2 from the labeling mixture with glucose oxidase, which consumes O 2 upon oxidation of its substrate glucose 31
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