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In chronic or adjunctive settings, ongoing monitoring is recommended to avoid toxicity
2004 Violi, F et col
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However, at the start of the COVID-19 pandemic, both drugs were used to treat COVID-19 infections due to their ability to increase endosomal pH, inhibiting both the fusion of SARS-CoV-2 and the angiotensin-converting enzyme 2 (ACE2) receptor presented on the host cell membrane [54, 55]
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