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Importantly, localized increases in GLP-1, such as that occur in the gut and portal vein, often have a more profound effect than systemic elevations, emphasizing the therapeutic potential of targeting regional activity rather than relying solely on systemic concentrations

10.1038/s41598-022-26915-3 505 ZhanX.StamovaB.JinL.-W.DeCarliC.PhinneyB.SharpF