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Phase I trial of HuMax-IL8 (BMS-986253), an anti-IL-8 monoclonal antibody, in patients with metastatic or unresectable solid tumors
The pattern of pGLP-1R expression (Fig
For context, the CSF exposure of monoclonal antibodies used in Alzheimers disease typically ranges from 0.1% to 0.3% of plasma concentrations, whereas small-molecule CNS drugs often exceed 5%, placing semaglutide within a low but pharmacologically plausible exposure range
2, Extended Data Fig
GIP receptor activation may further support insulin secretion and metabolic regulation
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