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Increased risk of low blood sugar (hypoglycemia): Especially in those who also take medicines to treat type 2 diabetes

A comparative study conducted between GLP-1RA + Metformin in contrast to cyproterone acetate/ethinylestradiol + Metformin in overweight PCOS women, conducted over a period of 12 weeks, implied that GLP-1 RA+Metformin was superior in reducing the waist circumferences as well as preserving blood sugar levels by improved HbA1c levels and regulating menstrual cycle

Weight loss with semaglutide is enhanced by a balanced diet and regular exercise

In clinical literature, the underlying phenomenon relates to how appetite-regulating hormones - particularly GLP-1, ghrelin, and leptin - interact with reward and satiety pathways in the brain

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