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To test the importance of sAC to the actions of GLP-1(2836), we used an in vivo IRI model in sAC / mice and compared this with WT littermate controls

59 Another important advantage of eGFR estimates based on cystatin C is that they may better correlate with the risk of developing cardiovascular disease and premature mortality

Its not due to the GLP-1 itself

The dosing ranges referenced are derived from preclinical research models and observational, non-clinical protocols

A biosimilar is a biological product that is similar to a reference biologic (usually the originally approved product) and for which there are no clinically meaningful differences in terms of safety, purity, and potency